Hey Jeff,
Like we talked about today, 425whp is possible on straight 93, but you'll need a big enough turbo to facilitate this without eating up fueling headroom with ethanol or having to use auxiliary fueling through methanol. I saw a guy make ~500whp on 93. He was on a built motor, though, and since our 93 sucks so much in Texas, I don't think that's a realistic goal for you. Even with decent fuel quality, folks on GT3071r turbos can usually only hit about 350whp on 93.
If you want 425whp and especially if you want to retain responsiveness (by not choosing a huge turbo), you'll need aux fueling for sure. Even on a mild E25 mix, we can only hit ~370-380 on a decently responding turbo, like a BNR S3, GTX2867r, etc., before we run out of headroom. And that's with the extra timing availed through the alky in your tank. To do it on 93 with TX fuel quality is impossible, IMHO, especially with our crappy fuel, like I mentioned.
I'd just run in-tank ethanol and a CM10 or CM14 to hit 425 with 100% methanol. You will have to be tuned for it, and you will be fueling dependent. These cars simply just don't have enough fueling headroom to hit 425 on 93 yet still remain responsive. You'll likely need at least a 35-frame turbo, and it'll be a dog around town. Plus, 425whp is a LOT of heat for stock rings to handle with zero alky flowing to keep the combustion chamber cool and safe. You very well likely may get rind-end butting and pop a ringland; then you'll need to look at rebuilding the motor.
Maybe 
@Atvfreek or 
@Jason@DizzyTuning can jump in here and give you a pro opinion far beyond my level of knowledge.